Most people who build DDK/WDK projects in Visual Studio do so using a 'makefile' project that invokes the DDK's build.exe
utility. This works quite well- you get the code navigation capabilities of Visual Studio while building your DDK project using the standard, supported DDK tools.
Note that the DDK comes with it's own set of compilers, and those compilers should be used to build DDK projects.
OSR has a little set of cmd scripts that is supposed to make this easier (it's been years since I've done anything with those; I really can't remember how well they work):
Another similar tool is available from Hollis Technology:
As far as debugging goes, unfortuantely the VS debugger won't work for kernel mode driver debugging. For that, get the Debugging Tools for Windows package which has a great set of debuggers. The GUI debugger, WinDbg, is quite nice even if it's not quite up to the usability of Visual Studio's. And the documentation with the Debugging Tools is outstanding - you can learn a lot about Windows internals just by reading the WinDbg docs.