lock-in

Chrome or Firefox (or browser-agnostic) for an intranet app?

If you were designing a core business intranet app for a small business, and wanted it to be as responsive-feeling as possible, where the staff are indifferent to being stuck with a certain browser, would you design for Firefox, Chrome, or test more widely than you need to just to avoid lock-in? Are there other factors you'd consider be...

Breaking out of the Google App Engine Python lock-in?

Are there any guidelines to writing Google App Engine Python code that would work without Google's infrastructure on other platforms? Is there any known attempt to create an open source framework which can run applications designed for Google App Engine on other platforms? Edit: To clarify, the question really is: If I develop an app...