What's missing from your callstack? Do you have a bunch of addresses that don't resolve to valid function names (ie, 0x8732ae00 instead of CFoo:Bar())? If so, then what you need is to put your .PDBs where your debugger can find them, or set up a symbol server and set the "Symbol Paths" in the right-click context menu of the Modules pane.
We store every .PDB from every binary every time someone checks in a new Perforce changelist, so that when a dump comes back from anyone inside the office or any customer at retail, we have the .PDB corresponding to the version of the game they were running. With the symbol server and paths set, all I have to do is just double-click the .mdmp and it works every time.
Or do you have a call stack that appears to only have one function in it? Like, 0x8538cf00 without anything else above it in the stack? If so, then your crash is actually the stack itself being corrupted. If the return addresses in the backchain have been overwritten, naturally the debugger will be unable to resolve them.
Sometimes also you'll find that the thread that actually emits the minidump is not the one that threw the exception that caused the crash. Look in the Threads window to see if one of the other threads has the offending code in it.
If you are debugging a "Release" build -- that is to say, one compiled with all optimization flags turned on -- you will have to live with the fact that the debugger will have trouble finding local variables and some other data. This is because turning on optimizations means allowing the compiler to keep data on registers, collapse calculations, and generally do a variety of things that prevents data from ever actually being written to the stack. If this is your problem then you'll need to open up the disassembly window and chase the data by hand, or rebuild a debug binary and reproduce the problem where you can look at it.