Threads make the design, implementation and debugging of a program significantly more difficult.
Yet many people seem to think that every task in a program that can be threaded should be threaded, even on a single core system.
I can understand threading something like an MPEG2 decoder that's going to run on a multicore cpu ( which I've done ), but what can justify the significant development costs threading entails when you're talking about a single core system or even a multicore system if your task doesn't gain significant performance from a parallel implementation?
Or more succinctly, what kinds of non-performance related problems justify threading?
Edit
Well I just ran across one instance that's not CPU limited but threads make a big difference:
TCP, HTTP and the Multi-Threading Sweet Spot
Multiple threads are pretty useful when trying to max out your bandwidth to another peer over a high latency network connection. Non-blocking I/O would use significantly less local CPU resources, but would be much more difficult to design and implement.