What are the Drawbacks of large binaries?

Question

I ask since a project I work on generates a single, monolithic DLL of about 50 MB size.

Does a large library like this one impede performance, or can it bring other gotchas?

UPDATE: I work with Embercadero RAD Studio Delphi 2010 on Windows (XP|Vista|7).

Answer 1

In .NET, you should prefer a few large assemblies rather than many small assemblies.

See: Does .NET assembly size affect performance?