I'm a big fan of screen real estate. I love big monitors and multiple monitors. I ran dual 19" CRTs for years, and switched to dual 19" LCDs a few years ago. That's still what I run at home, but I recently started a new job where I wrangled a big hardware budget and promptly blew a bunch of it on twin 24" monitors. I really love these screens, but I feel like I'm not getting the most out of them.
Two big, widescreen monitors like these really feels like four regular monitors to me, since I can keep four web browsers or word documents open at the same time. I'll occasionally fill a whole screen with a single program (usually an IDE or Excel) but that's the exception. Problem is I'm having trouble using more than three windows at a time (yeah, I know, poor me right?). Either the extreme right or the extreme left of my screen just ends up getting neglected, either remaining empty or holding some Firefox instance that was related to whatever I was doing an hour ago. So I'm asking those with experience with enormous amounts of screen real estate (triple monitors or dual widescreens), what's the best way to put all that area to good use?
Edited to add: Lots of good answers, but I just had to accept mauriciopastrana's because Earthdesk is simply awesome. Thank you all.