I spend most of my time on the care and maintenance of probably the largest Bugzilla database, with over 3 million rows in its bugs
table. Issues in it are described in many different languages, but of course, as soon as you start using UTF-8, that doesn't really matter.
We're using an extensively modified fork of an old Bugzilla version, although I'm working right now on merging our code into Bugzilla 3.6.
I would recommend Bugzilla for your needs, except that you mentioned content/editorial issues. For better or worse, Bugzilla is a bug-tracking system. Things that aren't really bugs in software don't map well into what Bugzilla does well, and Bugzilla doesn't do very well the sorts of things that non-programmers want.
Honestly, I think you should use different systems for what are basically different applications. I don't know what capabilities are important for content/editorial issuer tracking, but I suspect it's different from bug tracking.