Here's a function to draw an arrow with its head at a point p. You would set this to the midpoint of your line. dx and dy are the line direction, which is given by (x1 - x0, y1 - y0). This will give an arrow that is scaled to the line length. Normalize this direction if you want the arrow to always be the same size.
private static void DrawArrow(Graphics g, Pen pen, Point p, float dx, float dy)
{
const double cos = 0.866;
const double sin = 0.500;
PointF end1 = new PointF(
(float)(p.X + (dx * cos + dy * -sin)),
(float)(p.Y + (dx * sin + dy * cos)));
PointF end2 = new PointF(
(float)(p.X + (dx * cos + dy * sin)),
(float)(p.Y + (dx * -sin + dy * cos)));
g.DrawLine(pen, p, end1);
g.DrawLine(pen, p, end2);
}