A 64-bit OS should help you out a bit here, if you get more than 4GB of physical RAM. A 64-bit OS can provide 32-bit processes with a full 4 GB of virtual memory, whereas a 32-bit OS only can provide 2 or 3 gigs at best, depending on how you boot the OS.
That being said, 100 projects is a pretty fat solution file. Maybe now would be a good time to reexamine that decision...
EDIT: Running dumpbin /headers as prescribed in the article for DEVENV.EXE returns:
File Type: EXECUTABLE IMAGE
FILE HEADER VALUES
14C machine (x86)
4 number of sections
4BA1FAB3 time date stamp Thu Mar 18 06:04:35 2010
0 file pointer to symbol table
0 number of symbols
E0 size of optional header
122 characteristics
Executable
Application can handle large (>2GB) addresses
32 bit word machine
So that would indicate that an x64 box with > 4GB of RAM will probably improve your experience. You should have up to twice as much VM available for Visual Studio under a 64-bit OS...