How can I set the SelectedIndex in a ComboBox having element binding?

Question

Hi, I have two ComboBoxes, one for Organisation and one for Region. When selecting Organisation I want the Region combobox to update itself with the related regions. After selecting Organisation and Region I can type in a Site to a textbox and store it to db (ADD mode). I've completed that with this code:

<ComboBox x:Name="cbOrganisation"
      Grid.Row="0"
      Grid.Column="1" 
      ItemsSource="{Binding OrganisationEntries}"
      SelectedItem="{Binding SelectedOrganisation, Mode=TwoWay}"
      SelectedIndex="{Binding SelectedOrganisationIndex}"
      DisplayMemberPath="Description">
</ComboBox>

<ComboBox x:Name="cbRegions"
    Grid.Row="1"
    Grid.Column="1" 
    ItemsSource="{Binding ElementName=cbOrganisation, Path=SelectedItem.Regions}"
    SelectedItem="{Binding SelectedRegion, Mode=TwoWay}"
    SelectedIndex="{Binding SelectedRegionIndex}"
    DisplayMemberPath="Description" >
</ComboBox>

So, I'm using element to element binding, with the second combobox having the first one as ItemSource.

Now, I've got a new problem when I want to EDIT a site in my collection. In EDIT mode, I want the two dropdowns to be preselected and disabled (BusinessRule is that I can edit the sitename, not which organisation og region it's connected to). So by setting the SelectedIndex property on Organisation combobox I get my organisation selected, but when doing the same on the Regions combobox it fails with an Object Reference error. Any clue what I'm doing wrong?