I think the problem is that when the Grid is drawn, it draws each row from top to bottom, and within each row the items left to right. So the row-spanned <mx:TextArea> item is drawn first extending down into the area of the 2 next rows, which get drawn after and on top.
The quickest way around I can see would be to draw the row borders on the <mx:GridItem>s instead, skipping the left and right edges based on the item's placement in the row. Something like this:
<?xml version="1.0" encoding="utf-8"?>
<mx:Application xmlns:mx="http://www.adobe.com/2006/mxml" layout="absolute">
<mx:Style>
Grid {
background-color: white;
horizontal-gap: 0;
}
GridItem {
padding-top: 5;
padding-left: 5;
padding-right: 5;
padding-bottom: 5;
background-color: #efefef;
border-style: solid;
border-thickness: 1;
border-color: black;
}
.left {
border-sides: top, bottom, left;
}
.right {
border-sides: top, bottom, right;
}
.center {
border-sides: top, bottom;
}
</mx:Style>
<mx:Grid>
<mx:GridRow>
<mx:GridItem styleName="left">
<mx:Label text="Label"/>
</mx:GridItem>
<mx:GridItem styleName="center">
<mx:ComboBox/>
</mx:GridItem>
<mx:GridItem styleName="center">
<mx:Label text="Label"/>
</mx:GridItem>
<mx:GridItem styleName="right">
<mx:ComboBox/>
</mx:GridItem>
</mx:GridRow>
<mx:GridRow>
<mx:GridItem styleName="left">
<mx:Label text="Label"/>
</mx:GridItem>
<mx:GridItem styleName="center">
<mx:TextInput/>
</mx:GridItem>
<mx:GridItem colSpan="2" rowSpan="3">
<mx:VBox width="100%" height="100%">
<mx:Label text="Label"/>
<mx:TextArea width="100%" height="100%"/>
</mx:VBox>
</mx:GridItem>
</mx:GridRow>
<mx:GridRow>
<mx:GridItem styleName="left">
<mx:Label text="Label"/>
</mx:GridItem>
<mx:GridItem styleName="center">
<mx:TextInput/>
</mx:GridItem>
</mx:GridRow>
<mx:GridRow>
<mx:GridItem styleName="left">
<mx:Label text="Label"/>
</mx:GridItem>
<mx:GridItem styleName="center">
<mx:TextInput/>
</mx:GridItem>
</mx:GridRow>
</mx:Grid>
</mx:Application>