It's peculiar this issue is not well understood on NVIDIA forums and project forums.
For example, the well known ioquake3 project based on id tech 3 requires to force 'Threaded optimization' off on the NVIDIA settings or there are severe FPS drops.
Do you know what a programmer has to do to acquire compatibility with the feature or at least a workaround to not get issues with it (e.g. turning it off explicitly via the application or other means)?
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The main importance is that such projects get issues with it by default since not all users know they have to explicitly turn off the feature.