Go with your gut, its usually right.
I had a planned severance situation a couple of years back and I ended up with six job offers. I used a very complex pros/cons method of determining which job to take. I ended up taking the job that made the most "sense" using a variety of hard factors (compensation, commute, benefits, flexibility, industry, size/stability, etc). However, I also had a funny/bad feeling about the one I ended up taking. Within a week after I started, I realized I would never really enjoy working there. The funny thing is, my manager was great, I got to work from home once a week, the compensation/benefits were really good, and I was working on an important project using the latest tools. But the corporate culture just wasn't a fit for me and I wasn't happy.
I left 9 months later for a work-from-home for a small company gig I'm still at now.