In general, what kinds of design decisions help an application scale well?
(Note: Having just learned about Big O Notation, I'm looking to gather more principles of programming here. I've attempted to explain Big O Notation by answering my own question below, but I want the community to improve both this question and the answers.)
Responses so far
1) Define scaling. Do you need to scale for lots of users, traffic, objects in a virtual environment?
2) Look at your algorithms. Will the amount of work they do scale linearly with the actual amount of work - i.e. number of items to loop through, number of users, etc?
3) Look at your hardware. Is your application designed such that you can run it on multiple machines if one can't keep up?
Secondary thoughts
1) Don't optimize too much too soon - test first. Maybe bottlenecks will happen in unforseen places.
2) Maybe the need to scale will not outpace Moore's Law, and maybe upgrading hardware will be cheaper than refactoring.