As we did this in the past, i'd like to gather useful information for everyone moving to loadbalancing, as there are issues which your code must be aware of.
We moved from one apache server to squid as reverse proxy/loadbalancer with three apache servers behind.
We are using PHP/MySQL, so issues may differ.
Things we had to solve:
Sessions
We moved from "default" php sessions (files) to distributed memcached-sessions. Simple solution, has to be done. This way, you also don't need "sticky sessions" on your loadbalancer.
Caching
To our non-distributed apc-cache per webserver, we added anoter memcached-layer for distributed object caching, and replaced all old/outdated filecaching systems with it.
Uploads
Uploads go to a shared (nfs) folder.
Things we optimized for speed:
Static Files
Our main NFS runs a lighttpd, serving (also user-uploaded) images. Squid is aware of that and never queries our apache-nodes for images, which gave a nice performance boost. Squid is also configured to cache those files in ram.
What did you do to get your code/project ready for loadbalancing, any other concerns for people thinking about this move, and which platform/language are you using?