Piece of advice: you are doing a software antipattern. You are making architecture part of the design. You have bad feelings to product X for unfounded reasons (you said yourself you are not very familiar with the techs) Say product X would be able to solve your problem on time and on budget at half the cost.. Wouldnt you be totally nuts to go with product Y just because you have bad dreams of world domination? I think if your company is to be successful you have to have a more mature mindset.
In this case however I dont think Silverlight would be suitable for what you want. I know silverlight does not have the audio capabilities to interface with the Mic in this release. But then again Flex does not have desktop privileges either, not without AIR anyway. But AIR apps do need to be installed since they are like a Leech on the users system :-) They arent really webapps anymore.
And you shouldnt compare Silverlight to AIR as they are completely different platforms. AIR runs apps on the desktop. You should compare AIR apps against .NET Framework 3.5 / WPF apps and I know between those two where I would put my money on. And so what if your app only runs on 90% of the PC's when you code on the .NET framework 3.5... In fact, this is actually the main argument for Flash people over Silverlight.. So if its Flash - Silverlight -> 90% is wonderful penetration! If its developing a Windows app.. Hey you cant leave out the other 10% minorty! hehe. Just goes to show its not black and whites.
Also installing a plugin is not a big deal. Flash does not support Native HD streaming video without a plugin. Yet to install this HD plugin, people have no problem with that. Yet when installing a Silverlight plugin it all of a sudden becomes a problem to some people.
There would also need to be some kind of server infrastructure behind your product. I doubt you will be able to code the servers in ActionScript. You're looking at something more performant then. And simply put when you're competing with a product like Skype, VOIPBuster and the gazillion other VOIP services (some even for free) you have to wonder if you're even endeavouring on a profitable application.
Also you say you have only one month experience in either platform. I'd recommend first in getting more development experience in general before moving on to a huge project to take on the world. There's a lot to learn.
Microsoft wants to conquer the world, that may be true but that is the holy grail for all companies :-) And its funny, you say you dont want Microsoft to own the world, yet you see your own application dominating it... - Facts is: any company is out to make a profit whether it is Google, Adobe or Microsoft.
But hey, you can always write a Java program and be really cool :-)