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I have some applications running under IIS6 and they all simply stopped working some time ago. Initially I suspected that could be any patch applied to our servers but I got the information that none have been applied in this time window.

The error message that is thrown by IIS is "Invalid Index", which is a HTTP 500 error. I thought that this could be related to .NET malfunction so I have the frameworks 1.1/2/3/3.5 uninstalled but the application server is still unable to handle the most simple request, such as simple HTML files or images.

I have checked the IIS log and Event Viewer but I could not extract any relevant information. The MIME mappings are ok as well as IIS metadata and Server Extensions.

Since I am running out of alternatives I would like to know if someone have ever faced such error and how it was handled.

PS: I unfortunately have a constraint: I am not authorized to reinstall IIS at any means. At least, this far..

Thank you.