I just heard one of the clients having really bad performance on IE6 despite modern hardware and decent network connection. So we are suspecting either one or both to be the reason for the bad performance. Unfortunately no exact details of firewalls or such known at the moment...
What kind of issues you have had with web applications using AJAX heavily because of virus scanners or strange corporate network filters? And what kind of approach you have used to tackle them?
edit: Application on IE6 has been tested elsewhere and it performed well enough.