It's a tossup between the Tektronix 4051 desktop graphics microcomputer and the HP 250 mini.
The Tek was an astounding piece of hardware for 1978. It used Tektronix's bizarre storage-tube graphics technology, which was kind of like a plotter that used electrons instead of ink. It had a built in BASIC interpreter for programming, something like 64K of memory, and, for virtual memory, a streaming-tape-cartridge drive. Yes, not only were programs broken up into segments that you could load dynamically into the shared buffer, they were loaded off of tape. This made UI design a challenge.
It also had programmable function keys (and plastic overlays that you could label your program functions on!) and, for coordinate input, X and Y thumbwheels that positioned the crosshairs on the screen wherever you wanted. It was immensely heavy and immensely expensive. I think when we finally were able to replace the tape drive with an external floppy disk drive (and man, was that an improvement), the price tag was around 10 grand.
The HP 250 was something else entirely. It was a small-office minicomputer system that could support up to five users (barely), four of them using custom HP 250 terminals, and the fifth seated at the big white plastic desk of the administrator's console. The main console was an elegant thing that may or may not have ever won any European design awards, but that was sure the look they were shooting for.
The terminals all featured a row of eight programmable function keys across the bottom of the screen, which could all be labeled dynamically under software control. This, coupled with the forms-management software, could make for some pretty decent user interfaces for 1980. The other software bundled with the 250's OS was HP's IMAGE database, a report writer, and of course to program it all with, HP 250 BASIC.
It was a sweet machine, and fantastically expensive, and the moment the IBM PC came out, Mr. Hewlett and Mr. Packard looked at each other, shrugged, and took Old Yeller out back and shot him in the head. Kind of unfortunate for those software vendors who'd built their business on it. I believe my company actually got a settlement from HP, though I wasn't privy to the details.
And then we switched over to PR1ME, but that's another story. (Our PR1ME sales rep, an otherwise nice guy, went on to become CEO of one of the most hated malware vendors in the industry.)