General Advice
I doubt you'd be comfortable with flanking monitors on a 28" unless you're sitting far enough away -- my 27" essentially fills most of my field of view. Additionally, you probably would prefer to have all 3 be the same resolution to make it easier to go back and forth (visually and window-dragging).
It really comes down to what you're doing, though. Some people just can't get enough pixels, whereas others are fine once they've got enough physical real estate to position their common windows all visible together.
Problems
I tried to use my Laptop in combination with my primary PC's 19" display (via the fantastic Synergy program), but even the difference between 1280x1024 and 1400x1050 drove me crazy (not to mention screen brightness differences).
Software
You'll definitely want some extra software to aid in window management across multiple monitors. Ultramon is pretty highly-recommended for things like separate screensavers and intelligent taskbars. If you're finding yourself with a large monitor and needing to quickly position windows, Winsplit (picked up from Jeff's advice, of course) is awesome.