I remember from my old BASIC programming days that for extra performance, you could use a BASIC compiler (instead of the runtime interpreter), but for ultimate performance, the answer was assembly code.
Today, when performance is crucial, I guess assembly language is still the ultimate optimisation answer. Going for a less extreme solution, many seem to write parts of their application in C/C++ to optimise bottlenecks.
This leads me to wonder what "benchmark tests" are published on the performance of various programming language implementations. I guess such tests will be most "truthful" when comparing implementations of the same programming language, but they could also provide some insight on how much is to be gained in speed by writing parts of an application in a different programming language.
Some nice references have been given here, but they are not very recent. I would be interested to see more comparisons of .NET and Java implementations.